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Risk of type 2 diabetes and cumulative excess weight exposure in the Framingham Offspring Study |
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| Authors: | Danielle R. Bouchard Bianca Porneala Ian Janssen Marie-France Langlois Jean-Patrice Baillargeon Caroline S. Fox James B. Meigs Ralph B. D'Agostino Michael Pencina Marie-France Hivert |
| Affiliation: | 1. Faculty of Kinesiology and Recreation Management, University of Manitoba Winnipeg MB, Canada;2. Health, Leisure, and Human Performance Research Institute, Winnipeg MB, Canada;3. National Center for Biotechnology Information, Bethesda, MD, USA;4. Department of Community Health Epidemiology Queen''s University, Kingston, ON, Canada;5. School of Kinesiology and Health Studies, Queen''s University, Kingston, ON, Canada;6. Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Sherbrooke QC, Canada;7. Étienne-LeBel Clinical Research Center of the Centre hospitalier universitaire de Sherbrooke, Sherbrooke QC, Canada;8. Framingham Heart Study, Framingham, MA, USA;9. Department of Endocrinology, Brigham Women''s Hospital, Boston, MA, USA;10. General Medicine Division, Massachusetts General Hospital, Boston, MA, USA;11. Harvard Medical School, Boston MA, USA;12. Boston University Department of Mathematics and Statistics, Boston University, Boston, MA, USA;13. Boston University Department of Biostatistics, Boston University, Boston, MA, USA |
| Abstract: | AimMid-life obesity is associated with T2D risk. However, less is known about the cumulative effect of obesity during adulthood.MethodsFramingham Offspring Study participants who had an examination at 35 ± 2 years and were initially free of T2D were included in this study (N = 1026). A cumulative excess weight (CEW) score (year*kg/m2) was calculated until T2D diagnostic or the end of follow-up.ResultsEighty-four individuals (8.2%) developed T2D over 20 ± 6 years. Mean CEW scores were 118.0 ± 114.6 year*kg/m2 in individuals who developed T2D and 30.2 ± 91.4 year*kg/m2 in those who did not develop T2D (P < 0.01). T2D risk was doubled for each standard deviation increase in the CEW score (OR = 1.99 [1.64-2.40]; P < 0.001). However, CEW score was only significantly associated with T2D incidence for participants with a baseline BMI < 25 kg/m2 (OR = 2.13 [1.36–3.36]; P < 0.001).ConclusionsAccumulating weight between the mid-thirties to the mid-fifties increases the risk of developing T2D. However, BMI in mid-thirties remains a stronger predictor of T2D risk. |
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