Waist-to-thigh ratio is a predictor of internal organ cancers in humans: findings from a cohort study |
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| Authors: | Kuang-Hung Hsu Chia-Pang Shih Pei-Ju Liao |
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| Institution: | 1. Laboratory for Epidemiology, Department of Health Care Management, Chang Gung University, Taoyuan, Taiwan;2. Healthy Aging Research Centre, Chang Gung University, Taoyuan, Taiwan;3. Department of Health Care Administration, Oriental Institute of Technology, New Taipei City, Taiwan;4. Department of Business Administration, National Taiwan University, Taipei, Taiwan;1. Medical School Twente, Medisch Spectrum Twente, Enschede, The Netherlands;2. Department of Pulmonary Medicine, Medisch Spectrum Twente, Enschede, The Netherlands;3. Department of Research Methodology, Measurement, and Data Analysis, University of Twente, Enschede, The Netherlands;4. University Of Groningen, University Medical Centre Groningen, Department of Pulmonary Medicine, and Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands;5. Department of Pneumology, Medisch Centrum Alkmaar, Alkmaar, The Netherlands;6. Department of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Milan, Italy;7. Department of Pneumonology, University Thessaly Medical School, Larissa, Greece;8. Faculty of Medicine, University of Belgrade, Belgrade, Serbia;9. Clinic for Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia;10. Clinic of Pneumology and Respiratory Cell Research, University Hospital Basel, Basel, Switzerland;1. Asan Medical Center, Seoul, South Korea;2. Adventist Wockhardt Heart Institute, Surat Gujarat, India;3. Queen Alia Heart Institute, Amman, Jordan;4. Mayo Clinic, Rochester, MN USA;5. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN USA;6. Case Medical Center, Case Western Reserve University, Cleveland, OH USA;1. School of Public Health, Anhui Medical University, Hefei, China;2. Department of Respiratory Medicine, The Second Hospital of Anhui Medical University, Hefei, China;1. Department of Community Health and Psychiatry, University of the West Indies, 3 Gibraltar Camp Way, Mona, Kingston 7, Jamaica;2. International Biostatistics and Information Services, Anse O''Quille, Marisule, Gros Islet, St Lucia;3. Health Research Resource Unit, Faculty of Medical Sciences, Teaching and Research Complex, University of the West Indies, Mona, Kingston 7, Jamaica;1. Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark;3. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark;4. Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark;6. Department of Gastroenterology, Inselspital, Bern, Switzerland;5. Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark;1. Nanophotonics Technology Center, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain;2. Institute of Theoretical Physics, Faculty of Mathematics and Physics, Charles University in Prague, V. Hole?ovi?kách 2, 180 00 Praha 8, Czech Republic;3. Instituto de Astrofísica de Andalucía (CSIC), Glorieta de la Astronomía, 18008 Granada, Spain;4. Modelling & Numerical Simulation Group, Universidad Carlos III de Madrid, Avda. de la Universidad, 30, 28911 Leganés, Madrid, Spain;5. Wave Phenomena Group, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain |
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| Abstract: | ObjectiveStudies have shown that some specific body measures are associated with the occurrence of cancers. Few studies have demonstrated the relationship with more comprehensive approaches. This study aims to explore body measures and the combinations associated with internal organ cancers.MethodsThree-dimensional anthropometric body surface scanning data collected 10,215 participants from the health examination department in a medical center of Taiwan during 2000–2010. Follow-up was conducted for an average of 8 years, and 244 internal organ cancer cases were identified.ResultsAn increased risk of internal organ cancers was observed among the subjects with larger waist circumference/smaller thigh circumference, in which waist-to-thigh ratio (WTR) was constructed. Comparing the subjects in the fourth quartile for WTR to the subjects in the first quartile with multiple Cox regression analysis yielded a hazard ratio of 1.842 (95% confidence interval, 1.131～2.999). The association between WTR quartile and internal organ cancers was stronger among male participants, older participants, and participants with chronic conditions.ConclusionsThe study has revealed that WTR is the most significant predictor for the occurrence of cancer in Asian populations. Because it is easy to measure and open to modification, WTR may be more useful in clinical and preventive medicine in the future. |
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