Effects of chronic morphine intake on binding of NAD and GABA-benzodiazepine agonists to synaptic membranes |
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| Authors: | A I Fomenko G V Donchenko S P Stepanenko |
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| Institution: | (1) A. V. Palladin Institute of Biochemistry, Ukrainian Academy of Sciences, Kiev, Ukraine |
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| Abstract: | Nine weeks of compulsory morphine drinking decreased the specific binding of3H-muscimol to GABA receptors and14C-NAD to rat brain synaptic membranes and increased the synaptosomal uptake of14C-GABA. These effects of morphine on the GABA-benzodiazepine receptor complex were reversed by excessive doses of vitamin
B3.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 295–301, March, 1999 |
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| Keywords: | vitamin B3 NAD morphine GABA-benzodiazepine receptor complex |
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