| 几种镍剂对小鼠致癌作用的实验研究 |
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| 引用本文： | 王朝俊,江映红,李玉琼,邓士林,罗德元,肖恒怡.几种镍剂对小鼠致癌作用的实验研究[J].四川大学学报(医学版),1989(3). |
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| 作者姓名： | 王朝俊 江映红 李玉琼 邓士林 罗德元 肖恒怡 |
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| 作者单位： | 华西医大肿瘤研究所
(王朝俊，江映红，李玉琼，邓士林，罗德元)，华西医大肿瘤研究所(肖恒怡) |
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| 摘 要： | 应用某镍冶炼厂作业环境中存在的几种镍剂,给三种小鼠右腋皮下注射,每鼠5mg,观察62周。仅见镍精砂(主要含Ni_3S_2)有局部诱癌作用。其病理组织学表现以纤维肉瘤为主,亦见2例横纹肌肉瘤,大多数肿瘤分化差,有浸润性,个别发生肝、肺转移。此结果提示该厂环境中存在的镍精砂可能对人类也具有致癌危险性,在考虑劳保措施和职业癌的防治中应引起足够重视。
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| 关 键 词： | 镍 小鼠 诱癌 纤维肉瘤 浸润 转移 |
STUDY ON CARCINOGENIC ACTIVITY OF SEVERAL NICKEL COMPOUNDS IN MICE |
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| Wang Chaojun,Jiang Yinghong,Li Yuqiong,Deng Shilin,Luo Deyuan,Xiao Hengyi Institute of Cancer Research.STUDY ON CARCINOGENIC ACTIVITY OF SEVERAL NICKEL COMPOUNDS IN MICE[J].Journal of West China University of Medical Sciences,1989(3). |
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| Authors: | Wang Chaojun Jiang Yinghong Li Yuqiong Deng Shilin Luo Deyuan Xiao Hengyi Institute of Cancer Research |
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| Institution: | Wang Chaojun;Jiang Yinghong;Li Yuqiong;Deng Shilin;Luo Deyuan;Xiao Hengyi Institute of Cancer Research |
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| Abstract: | This paper reports the result of thetumor in site induced by several nickelcompounds in mice. Three nickel com-pounds (Ni_3S_2, NiCl, pure nickel powder)were injected separately to the right armpitsubcutaneously (5mg/mouse). At the endof the 62nd week, the tested mice weresacrificed.Only nickel sulfide induced tu-mors in the site of injection, the incidenceof tumor was 36%. The majority of thetumors were fibrosarcomas, only 2 rhab-domyosarcomas. The tumors might infil-trate into the surrounding tissues, a fewmetastasized to the liver and/or the lungs. |
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| Keywords: | Nickel Mice Tumor induction Fibrosarcoma Infiltration |
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