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Vascular endothelial growth factor gene polymorphism (-634G/C) and breast cancer risk |
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| Authors: | Weirong Yao Rongzeng Yan Lin Ma Huiping Wan Yanmin Yu Xia Cheng Yingliang Li |
| Affiliation: | 1. Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China 2. Department of Oncology, People’s Hospital of Jiangxi Province, Nanchang, China 3. Chinese People’s Armed Police Forces Jiangxi General Hospital, Nanchang, China 4. Department of General Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, China |
| Abstract: | The aim of this meta-analysis was to assess if the -634G/C polymorphism represents a predisposition factor for the risk of breast cancer. We included eight published case-control studies, in which a total of 6,175 cancer cases and 6,421 cancer-free controls were included. Pooled ORs and 95 % CIs were calculated by the fixed effects model to evaluate the association of the -634G/C polymorphism and breast cancer risk. When all studies were pooled, we did not find statistical evidence of any significant association with overall breast cancer risk (ORBB vs. bb?=?1.00, 95 % CI?=?0.93–1.07, P?=?0.999; ORBB + Bb vs. bb?=?1.00, 95 % CI?=?0.95–1.05, P?=?0.999; ORBB vs. Bb + bb?=?1.03, 95 % CI?=?0.96-1.09, P?=?0.984; ORallele B vs. allele b?=?1.01, 95 % CI?=?0.97–1.05, P?=?0.998; ORBb vs. bb?=?0.99, 95 % CI?=?0.92–1.06, P?=?0.992). In further stratified analyses by ethnicity and control source, no significant association was revealed. This study suggests that the -634G/C polymorphism does not appear to represent a risk factor for breast cancer. |
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