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Potent antitumor activity of HSP90 inhibitor AUY922 in adrenocortical carcinoma
Authors:Junchao Huang  Chengchao Sun  Ting Zhang  Lei Pan  Suqing Wang  Qiqiang He  Dejia Li
Affiliation:1. Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, 437100, China
2. Department of Occupational and Environmental Health, School of Public Health, Wuhan University, 115 Donghu Road, Wuhan, 430071, China
Abstract:The objective of this study is to investigate the expression of HSP90 and the effect of HSP90 inhibitor AUY922 in ACC. The expression of HSP90 was measured in tissue samples from 36 human sporadic adrenocortical tumors by immunohistochemistry, Western blotting, and real-time PCR. The effect of AUY922 was tested on SW13 and H295R cells by evaluating cell viability and apoptosis in vitro. Transwell assay was performed to evaluate the migration of SW13 cells after different concentrations of AUY922. Western blot, real-time PCR, and immunohistochemistry revealed that both HSP90 mRNA and protein were obviously expressed in a higher degree in ACC tissues than ACA tissues and normal adrenal tissues (P?P?
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