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Aptamer TY04 inhibits the growth of multiple myeloma cells via cell cycle arrest |
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| Authors: | Hongjuan Dai Mao Ye Mingyuan Peng Weihua Zhou Huarong Bai Xiaojuan Xiao Bianying Ma Jiajie Zhou Shijun Tang Shan Yao Ye Cao Zhiqiang Qin Jing Liu Weihong Tan |
| Affiliation: | 1. Molecular Biology Research Center, School of Life Sciences, Central South University, Changsha, 410078, China 2. Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, 410082, China 3. Department of Hematology, Xiangya Hospital, Central South University, Changsha, 410008, China 4. National Institute of Parasitic Diseases, China CDC, Shanghai, 200025, China |
| Abstract: | The aptamer TY04 is a single-stranded DNA. However, its biological function has not been elucidated. Here, we found that TY04 specifically bound to multiple myeloma cells MM.1S, and some membrane proteins on the surface of MM.1S cells constituted the target molecules of TY04. TY04 inhibited the growth of multiple myeloma cell lines, induced cell cycle arrest in mitosis, and resulted in a significant accumulation of binucleated cells. Following TY04 treatment, a concomitant increase in CDK1 and cyclin B1 expression occurred. In addition, TY04 treatment also resulted in a significant downregulation of γ-tubulin. Considering the unique advantages of aptamers, TY04 shows great potential as a drug candidate to treat multiple myeloma. |
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