T-cell co-stimulatory molecules: their role in allergic immune reactions. |
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| Authors: | T Kallinich K C Beier U Wahn P Stock E Hamelmann |
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| Affiliation: | Department of Paediatrics, Division of Pneumology and Immunology, Charité Medical University of Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. |
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| Abstract: | The development of allergic diseases, such as allergic asthma, depends upon the initiation and maintenance of T-helper cell type-2-skewed allergen-specific immune reactions. Although it is clear that susceptibility to this process is under genetic and environmental control, the fine-tuning and regulation of the type-2 T-helper cell immune response is not yet fully understood. In this second article in the present series, current understanding regarding the involvement of T-cells and antigen-presenting cells is summarised, with emphasis on the interaction between these two types of immune regulatory cells by means of co-stimulatory molecules. |
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