| 应用不同催化剂合成邻氨基苯甲腈的研究 |
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| 引用本文： | 操锋,任勇,华维一. 应用不同催化剂合成邻氨基苯甲腈的研究[J]. 中国现代应用药学, 2002, 19(3): 211-212 |
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| 作者姓名： | 操锋 任勇 华维一 |
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| 作者单位： | 南京,210009,中国药科大学新药研究中心 |
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| 摘 要： | 目的：研究邻氨基苯甲腈的合成方法。方法：采用醇碱、路易斯酸及金属氧化物等为催化剂，以靛红－3－肟为原料合成邻基苯甲腈。结果：合成的产率为71.2%，结构经熔点确证。结论：碱性催化剂优于路易斯酸性催化剂，金属氧化物催化适合于工业化生产。
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| 关 键 词： | 催化剂 合成 邻氨基苯甲腈 研究 药物中间体 |
Study on the synthesis of o-amino benzonitrile using different catalysis |
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| Cao Feng(Cao F,Ren Yong(Ren Y,Hua weiyi(Hua WY. Study on the synthesis of o-amino benzonitrile using different catalysis[J]. The Chinese Journal of Modern Applied Pharmacy, 2002, 19(3): 211-212 |
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| Authors: | Cao Feng(Cao F Ren Yong(Ren Y Hua weiyi(Hua WY |
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| Abstract: | OBJECTIVE:To study the synthesis of o amino benzonitrile.METHOD:Using basic, lewis acid and metal oxide as catalysis, o amino benzonitrile was synthesized from Isatin.RESULTS:The total yield of o amino benzonitrile was 71.2%. The final product was identified by melting point.CONCLUSION:Basic catalysis is superior to Lewis acid catalysis. Using metal oxide is suitable for industrialization. |
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| Keywords: | catalysis o amino benzonitride synthsis |
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