| 痔瘘熏洗剂两种不同剂型——水剂与凝胶剂的镇痛药效研究 |
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| 引用本文： | 吴本升,朱萱萱,达庆国,钱芳,周青,陈玉根. 痔瘘熏洗剂两种不同剂型——水剂与凝胶剂的镇痛药效研究[J]. 成都中医药大学学报, 2012, 35(3): 31-33 |
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| 作者姓名： | 吴本升 朱萱萱 达庆国 钱芳 周青 陈玉根 |
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| 作者单位： | 1. 南京中医药大学,江苏南京,210046
2. 南京中医药大学附属医院,江苏南京,210029 |
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| 基金项目： | 江苏省中医药科技项目(编号:LZ0935) |
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| 摘 要： | 目的:观察痔瘘熏洗剂的两种不同剂型、不同剂量的镇痛效果。方法:将动物随机分成5组:模型对照组、熏洗剂高剂量组、熏洗剂低剂量组、凝胶剂高剂量组、凝胶剂低剂量组;通过热板法及化学刺激法观察痔瘘熏洗剂的不同剂型、不同剂量的镇痛作用。结果:痔瘘熏洗剂和凝胶剂均能快速提高痛阈,而且随着载药量的增加,药效作用随之增强;在同等剂量的凝胶剂与熏洗剂的比较中,以凝胶高剂量效果最佳。结论:痔瘘凝胶剂具有良好的镇痛功效。
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| 关 键 词： | 痔瘘凝胶剂 痔瘘熏洗剂 镇痛 |
Study on Analgesic Effect of Zhi-lou-Xun-xi Gel and Zhi-lou-Xun-xi Agent |
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| Affiliation: | WU Ben-sheng,ZHU Xuan-xuan,DA Qing-guo,et al(Nangjing University of Traditional Chinese Medicine,Najing,210046,China) |
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| Abstract: | Objective:To study the different analgestic effect function of Zhi-lou-Xun-xi Gel and Zhi-lou-Xun-xi Agent.Methods:Animals were divided into five groups randomly including control group,Zhi-lou-Xun-xi Gel high dose group,Zhi-lou-Xun-xi Gel low dose group,Zhi-lou-Xun-xi Agent high dose group and Zhi-lou-Xun-xi Agent low dose group.The analgesic effect of Zhi-lou-Xun-xi was tested by observing the mouse′s reaction to the pain simulated by heat conduction and chemical stimulus.Results:Zhi-lou-Xun-xi Gel and Zhi-lou-Xun-xi Agent significantly increase hot-plate pain threshold in mice(P<0.05 orP<0.01) and markedly decreased times of body twist(P0.05);Zhi-lou-Xun-xi Gel high dose group is better than anyelse.Conclusion:Zhi-lou-Xun-xi Gel showed obvious analgesic effects. |
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| Keywords: | Zhi-lou-xun-xi gel Zhi-lou-xun-xi agent analgesic |
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