| Abstract: | Conclusion A negative correlation was found between adsorption of plasma proteins and surface affinity for AT-III. This correlation suggests that maximal activity of surface-bound HP and, therefore, maximal hemocompatibility of polymer material can be attained by minimization of adsorbed plasma proteins. The adsorbed layer is also enriched with AT-III. In addition, a negative correlation in the AT-III-RNAP pair shows that this condition is also necessary for decreasing risk of thrombosis, because it reduces the number of adhered platelets.Thus, high concentration of AT-III in the adsorbed layer is the specific feature of heparinized biomaterials which exerts a fundamental effect on cellular and molecular mechanisms of the interaction of blood with polymer materials.Scientific-Research Institute for Transplantology and Artificial Organs, Russian Ministry of Health, Moscow. Translated from Meditsinskaya Tekhnika, No. 2, pp. 18–22, March–April, 1994. |
