穴位经皮给药评价指标——药物传输系数研究

目的：探讨穴位经皮给药的皮肤电阻变化与血药浓度之间的相关关系,建立评价穴位药物传输效率的新指标。方法：将24只家兔随机分为穴位组和非穴位组。穴位组分别选择“肺俞”“膈俞”和“膻中”穴为给药部位,非穴位组以背部非穴位点为给药部位,测定氨茶碱贴剂穴位经皮给药后的皮肤电阻和血药浓度,考察其经时变化9以稳态时血药浓度值（C）和电阻变化值（R）的比值作为传输系数（DC）,观察穴位与非穴位传输药物的效率。结果：在给药6-8h左右C与R趋于稳态;各穴位给药的DC均远高于非穴位给药,差异有非常显著性意义（P〈0．01）,“肺俞”“膻中”的DC与“膈俞”相比,差异有非常显著性意义（P〈0．01）。结论：DC反映了穴位经皮给药的传输效率,DC越大,传输效率越高;穴位的传输效率较非穴位部位高;不同的穴位,DC也不同。

Study on evaluation index of acupoint transdermal administration--drug delivery coefficient

OBJECTIVE: To investigate the correlation of skin electric resistance changes with the blood drug content in acupoint transdermal administration, and to establish an new evaluation index for drug delivery efficiency through acupoints. METHODS: Twenty-four rabbits were randomly divided into an observation group and a control group. In the observation group, aminophylline was administrated through "Feishu" (BL 13), "Geshu" (BL 17) and "Danzhong" (CV 17) which are commonly used for treatment of bronchial asthma, and the control group through sham-points on the back. The skin resistance and plasma aminophylline content were determined after application of aminophylline to the points, and their changes with time were observed. The ratio of Css/Rss at stability was defined as delivery coefficient (DC) which reflects the efficiency of delivering drug at acupoints and sham acupoints. RESULTS: Both the plasma aminophylline and the skin resistance value tended to steady about 6-8 h after application of aminophyiophylline. The DC in the acupoints was higher than that in the sham-acupoints (P < 0.01). And there was significant difference as DC of the "Feishu"was significant difference (BL 13) and "Danzhongas DC of the "Feish" (BLCV 17) compared with that of "Geshu" (BL 17) (P < 0.01). CONCLUSION: The bigger the DC is, the higher the efficiency of drug delivery is; the efficiency of drug delivery through acupoints is higher than that through sham-acupoints.