慢性乙型肝炎患者血清铁、铁蛋白水平与脂质过氧化损伤的关系

目的 探讨慢性乙型肝炎(CHB)患者血清铁(SI)、铁蛋白(SF)水平与脂质过氧化损伤的关系.方法 选择79例CHB患者,用比色法测SI、放射免疫法测SF、硫代巴比妥酸法测丙二醛(MDA)、黄嘌呤氧化酶法测超氧化物歧化酶(SOD).结果 各组CHB患者SI、SF和MDA水平均高于对照组(P<0.05～0.01),SOD水平均低于对照组(P<0.01).79例CHB患者SI、FE水平与MDA水平均正相关(r=0.493,P<0.01;r=0.745,P<0.01);SI水平与SOD水平负相关(r=-0.27,P<0.05).结论 CHB患者SI、SF水平与脂质过氧化损伤有相关性,过重的铁负荷协同乙肝病毒加重肝损伤.

Relationship between serum Iron、Ferritin and lipid peroxidation injury in patients with chronic hepatitis B

Objective To investigate the relationship between serum iron(SI),serum ferritin(SF) and lipid peroxidation injury in patients with chronic hepatitis B.Methods 79 patients with chronic hepatitis B were enrolled in this study.SI was detected by chromatometry,SF by Radio-immunity,MDA by thiobarbituric acid method,and SOD by xanthineoxidase method.Results Compared to control group,the level of SI,FE and MDA in patients with chronic hepatitis B were higher significantly(P<0.05-0.01).On the contrary,the level of SOD in patients with chronic hepatitis B was lower significantly(P<0.01).In 79 patients with chronic hepatitis B,correlation analyses found that SI and FE were in positive correlation with MDA(r=0.493,P<0.01,r=0.745,P<0.01),and SI was in negative correlation with SOD(r=-0.27,P<0.05).Conclusion The levels of SI and SF in patients with chronic hepatitis B are closely related to lipid peroxidation injury,and the overload of iron may enhance the hepatocytes damage induced by HBV.