A series of case studies: practical methodology for identifying antinociceptive multi-target drugs |
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Authors: | Pang Min-Hee Kim Yuntae Jung Kyung Woon Cho Sunyoung Lee Doo H |
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Affiliation: | Biomedical Research Institute, Vivozon, Inc., Seoul, 136-703, Republic of Korea. |
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Abstract: | Since the introduction of drug discovery based on single targets, the number of newly developed drugs has steadily declined, and the reliablility of the current drug-discovery paradigm has been unceasingly questioned. As an alternative, an emerging approach pursuing multi-targeting drugs has arisen to reflect multifactorial diseases caused by the complex networks of various mechanisms. The purpose of this paper is to review multi-target drugs and introduce our progress in establishing a practical methodology for identifying antinociceptive multi-target drugs. We have adopted a system of ex vivo efficacy screening using long-term potentiation in rat spinal cord as a surrogate biomarker for neuropathic pain. A bait-target approach is also adopted to lure an unknown target combination that induces synergistic mechanisms. |
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