荔枝核皂苷改善高脂血症-脂肪肝大鼠胰岛素抵抗作用的机制研究

目的:研究荔枝核皂苷改善高脂血症-脂肪肝大鼠胰岛素抵抗(IR)的作用机制。方法:采用高脂血症-脂肪肝建立大鼠IR模型,观察荔枝核皂苷、罗格列酮、格列齐特对模型大鼠给药2h后空腹血清血糖(FSG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL -C)、肿瘤坏死因子(TNF) -α、胰岛素含量及胰岛素敏感指数(ISI)等指标的影响。结果:荔枝核皂苷能显著降低模型大鼠FSG、TC、TG、胰岛素含量及TNF -α浓度(P<0. 05或P<0 .01) ,并能显著提高HDL -C含量(P<0 .05)及ISI(P<0 .05) ,增强胰岛素敏感性。结论:荔枝核皂苷能调整高脂血症-脂肪肝所致的糖脂代谢障碍,改善模型大鼠高脂血症、高胰岛素血症及拮抗其IR ,提高胰岛素敏感性。

Study on the Mechanism of Litchi Saponin in Improving Action of Insulin Resistance in Rats with Hyperlipemia- Hepar Adiposum

OBJECTIVE:To investigate the mechanism of litchi saponin in impr oving action of insulin resistance(IR)in rats with hyperlipemia-hepar adiposum.METHODS:The hyperlipemia-hepar adiposum was used to establish IR model of rats,the effects of litchi saponin,roglitazone and gliclazide on the index of fasting serum glucose(FSG),total cholesterol(TC),triacylglycerol(TG),high density lipoprotein-cholesterol(HDL-C),tumor necrosis factor(TNF)-α,content of insulin,inˉsulin sensitivity(ISI)and so on were observed in the model rats2hours after medication.RESULTS:Litchi saponin could sigˉnificantly lower the level of FSG,TC,TG,contents of insulin and the concentration of TNF-α(P<0.05or P<0.01)of the model rats,which could also increase the content of HDL-C(P<0.05)and ISI(P<0.05)significantly and enhance the senˉsitivity of insulin.CONCLUSION:Litchi saponin can regulate glucolipid dysboism caused by hyperlipemia-hepar adiposum,improve hyperlipemia and hyperinsulinemia of model rats and resist the IR,which can increase insulin sensitivity as well.