Recovery of Natural Cytotoxicity After Bone Marrow Transplantation |
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Authors: | A Lange B Jazwiec B Tomaszewska-Toporska J Topotski |
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Affiliation: |
a Bone Marrow Transplantation Unit, K. Dluski Hospital, Grabiszynska, Wroclaw, Poland
b Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Grabiszynska, Wroclaw, Poland |
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Abstract: | Reconstitution of non-MHC restricted cytotoxicity was followed in 7 and in 4 cases after auto-and allotransplantation, respectively. In autografted cases a high level of natural cytotoxicity, which exceeded the pre-transplant values, was seen at the beginning of hematological reconstitution. At that time, the high percentage of DR+ peripheral blood mononuclear cells (PBMC) was found, while the percentage of CD16+ cells was in the range of the pre-transplant values. A high level of cytotoxicity was a transient phenomenon. In all cases, 40 days after grafting the natural cytotoxicity was again in the range of the pre-transplant values. In allotransplantation the peak of cytotoxicity was seen soon after the beginning of hematological recovery and the activity decreased after 24 to 48 days after grafting. |
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