In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis |
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Authors: | Karaarslan A Arikan S Ozcan M Ozcan K M |
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Affiliation: | Department of Microbiology and Clinical Microbiology, Ankara University Medical School, Ankara, Turkey. karaars@medicine.ankara.edu.tr |
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Abstract: | The minimum inhibitory concentrations (MIC, microg ml-1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38-P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC-2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC-0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125-1 and 0.06-0.5 microg ml-1 for A. niger (22 strains), 0.06-0.25 and 0.06-0.125 microg ml-1 for A. flavus (10 strains), 0.125 and 0.125-0.5 microg ml-1 for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested. |
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Keywords: | Aspergillus otomycosis terbinafine itraconazole antifungal susceptibility Aspergillus Otomykose Terbinafin Itraconazol Empfindlichkeit |
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