| 骨髓间充质干细胞移植修复大鼠半横断脊髓损伤 |
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| 引用本文： | 吴金生,董爱萍,王晓萃,魏志新,刘伟光,栾志敏,祝增军.骨髓间充质干细胞移植修复大鼠半横断脊髓损伤[J].实验动物与比较医学,2010,30(1):52-54. |
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| 作者姓名： | 吴金生 董爱萍 王晓萃 魏志新 刘伟光 栾志敏 祝增军 |
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| 作者单位： | 浙江中医药大学动物实验研究中心/比较医学研究中心,杭州,310053 |
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| 基金项目： | 1.浙江省公共科技基础平台项目，2.浙江省卫生高层次创新人才培养工程项目 |
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| 摘 要： | 目的探讨WHBE兔用于热原检查试验适用性。方法按照《中国药典》2005年版中对热原检测的要求，对WHBE兔进行测温。结果WHBE兔筛选一次性合格率为74．91％，与日本大耳白兔相当，但略高于普通级新西兰兔，且WHBE兔初筛体温分布频率呈正态分布，以38．5-39．5℃居多，且体重大小对WHBE兔合格率影响不明显。结论WHBE兔体温稳定，重复性好，适合用于热原检查试验。
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| 关 键 词： | WHBE兔 合格率 热原检查 |
Bone Marrow Mesenchymal Stem Cell Transplantation in the Repair of Rat Spinal Cord Hemisection Injury |
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| WU Jin-sheng,DONG Ai-ping,WANG Xiao-cui,WEI Zhi-xin,LIU Wei-guang,LUAN Zhi-min,ZHU Zeng-jun.Bone Marrow Mesenchymal Stem Cell Transplantation in the Repair of Rat Spinal Cord Hemisection Injury[J].Laboratory Animal and Comparative Medicine,2010,30(1):52-54. |
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| Authors: | WU Jin-sheng DONG Ai-ping WANG Xiao-cui WEI Zhi-xin LIU Wei-guang LUAN Zhi-min ZHU Zeng-jun |
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| Institution: | WU Jin-sheng~1,DONG Ai-ping~2,WANG Xiao-cui~3,WEI Zhi-xin~4,LIU Wei-guang~1,LUAN Zhi-min~1,ZHU Zeng-jun~1(1.Department of Urology,Affiliated Hospital of Weifang Medical College Weifang 261053,China,2.Lantian Hospital,Weifang 261042,3.Department of Human Anatomy,4.Laboratory of Morphology,Weifang Medical College,Weifang 261053) |
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| Abstract: | Objective To investigate the differentiation of bone marrow-derived mesenchymal stem cells into neurons and transplantation of the stem cells to repair rat hemisection spinal cord injury.Methods Adherent culture was used to isolate and culture rat bone marrow mesenchymal stem cells(MSCs).The rat spinal cord homogenate supernatant was used to induce neural differentiation of the 3rd generation cells.The nature of cell differentiation was identified by immunohistochemistry.The rat model of hemisection spinal ... |
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| Keywords: | Bone marrow Mesenchymal stem cells Spinal cord injury Induced differentiation Cell transplantation Rat |
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