甲氨蝶呤联合足叶乙甙、顺铂治疗绒毛膜癌耐药病例疗效分析

目的分析足叶乙甙、甲氨蝶呤、顺铂(EMP)方案治疗绒癌耐药病例的疗效,评价此方案的临床应用价值.方法回顾性分析了24例绒癌耐药病例应用EMP方案治疗后的临床疗效及毒副反应.结果24例经平均6.4个疗程化疗,15例获完全缓解(62.5%),6例部分缓解(25%),3例无效(12.5%).完全缓解后复发率为6.7%.结论EMP是治疗耐药滋养细胞肿瘤的安全、有效方案.

Methotrexate Combined Etopside and Cisplatin for the Treatment of Chemorefractory Choriocarcinoma

Objective:To evaluate the effectiveness and toxicity of combination chemotherapy with methotrexate,etopside and cispltain(EMP)for the treatment of chemorefractory choriocarcinoma.Methods:Twenty four patients of chemorefractory choriocarcinoma were treated with EMP regimen.The clinic effectiveness and toxicity were assessed after treatment .Results:The twenty four patients received 154 cycles of the study regimen,the median number of courses for each patients was 6.4.Fifteen cases(62.5%)achieved a complete remission.Six cases(25%)had a partial remission.Three (12.5%)showed nonresponse.Conclusion:EMP is an effective and safe regimen for the treatment of chemorefractory gestational trophoblastic tumor.It can be selected for treating chemorefractory choriocarcinoma.