Evidence for the involvement of the nitric oxide–cGMP pathway in the antinociception of morphine in the formalin test |
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Authors: | Vinicio Granados-Soto Marcelo de O Rufino Lúcia D Gomes Lopes Srgio H Ferreira |
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Institution: | Vinicio Granados-Soto, Marcelo de O. Rufino, Lúcia D. Gomes Lopes,Sérgio H. Ferreira |
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Abstract: | The effect of inhibition of nitric oxide synthesis and guanylate cyclase on the peripheral antinociceptive effect of morphine was assessed by using the formalin test in the rat. Saline, NG-monomethyl--arginine, a nitric oxide synthesis inhibitor (50 μg) and methylene blue, a guanylate cyclase inhibitor (500 μg), did not exhibit any antinociceptive activity. However, morphine (10 μg) produced a significant antinociceptive effect in phases 2a and 2b, which was reduced by pretreatment with either NG-monomethyl--arginine or methylene blue. These results suggest that the local administration of morphine induces antinociception by the activation of the -arginine–nitric oxide–cGMP pathway. |
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Keywords: | Morphine Methylene blue
Full-size image -arginine" target="_blank">NG-Monomethyl--arginine Formalin |
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