细胞外信号调节激酶蛋白在肺癌中的表达及意义

目的：检测细胞外信号调节激酶（ERK）在人肺癌和肺良性病变组织中的表达,探讨ERK蛋白与肺癌的组织类型、分化程度和淋巴结转移的关系。方法：选取77例肺癌标本和20例肺良性病变的组织,通过常规石蜡包埋行免疫组织化学染色,检测ERK2蛋白表达。结果：肺癌组和对照组ERK2蛋白表达的阳性率分别为51.9%和20.0%,两组间具有显著性差异（P〈0.05）。ERK2蛋白表达在肺癌不同病理类型即鳞癌和腺癌中无显著性差异（P〉0.05）。在高分化、中分化和低分化肺癌之间比较,ERK2表达阳性率有显著性差异（P〈0.05）。ERK2在有无淋巴结转移中有显著性差异（P〈0.05）。结论：肺癌组织中存在ERK2蛋白的高表达;ERK2蛋白的高表达与肺癌组织类型无关,而与分化程度和淋巴结转移有密切关系。因此,ERK2的表达与肺癌发生及发展的生物学行为和预后可能有关。

Expression of ERK2 in lung cancer tissue and their biological significances

Objective： To examine the expression of extracellular signal-regulated protein kinase 2 （ERK2） in lung cancer tissue and biological significances. Methods： Immunohistochemistry was used to detect ERK2 expression in 77 human lung cancer tissues and 20 benign pulmonary disease tissues. Results： ERK2 immunoreactivity increased significantly from 20.0% in benign pulmonary lesion tissues to 51.9% in lung cancer tissues （P0.05）. In addition, the expression level of ERK2 protein increased significantly with the difference of the differentiation cancer （P0.05）. The ERK2 immunoreactivity in creased significantly with lymph node metastasis of lung cancer （P0.05）. The over expression rates of ERK2 in adenocarcinoma and squamous cell carcinoma were not significantly different （P0.05）. Conclusion： An increased ERK2 expression is seen in lung carcinogenesis and metastasis. ERK2 may be associated with the carcinogenesis, biological behaviors and prognosis of lung cancer.