Involvement of central and peripheral cannabionoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine |
| |
Authors: | D S Ugdyzhekova Y G Davydova L A Maimeskulova R Mechoulam |
| |
Institution: | (1) Tomsk State Pedagogical University, Tomsk, Russia;(2) Jerusalem University, Israel |
| |
Abstract: | Intravenous injection of the selective cannabinoid receptor agonist HU-210 in doses of 0.05 and 0.25 mg/kg increased heart
resistance to arrhythmogenic effects of epinephrine, while intracerebroventricular infusion of this substance had no effect
on the incidence of epinephrine-induced arrhythmia. The selective antagonist of type I cannabinoid receptors SR141716A in
a dose of 3 mg/kg and ganglion blocker hexamethonium in a dose of 10 mg/kg did not modify the antiarrhythmic effect of HU-210.
This effect of HU-210 is probably related to activation of type II peripheral cannabinoid receptors.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 11, pp. 552–554, November, 2000 |
| |
Keywords: | cannabionoid receptors epinephrine-induced arrhythmia |
本文献已被 SpringerLink 等数据库收录! |
|