The meaning of the c-kit proto-oncogene product in malignant transformation in human mammary epithelium |
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Authors: | Chang Dae Ko Jee Soo Kim Byung Gyun Ko Byung Ho Son Hee Joon Kang Ho Sung Yoon Eun Yoon Cho Gyungyub Gong Sei Hyun Ahn |
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Institution: | (1) Departments of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea;(2) Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea |
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Abstract: | To evaluate the relationship between the c-kit proto-oncogene product and malignant transformation of human breast tissue,
we examined the immunohistochemical expression of the c-kit proto-oncogene product in both malignant and non-malignant breast
tissues. The immunohistochemical expression of the c-kit proto-oncogene product in 40 primary breast cancer tissues (22 axillary
lymph nodes negative, 18 lymph nodes positive), in 18 corresponding axillary lymph nodes, and in 10 distant metastastic tissues
were studied using an anti-c-kit proto-oncogene product antibody in comparison with 20 normal and 20 benign breast tissues.
The mean values of immunoreactive score (IRS) were compared. The IRS of the c-kit proto- oncogene product in normal mammary
epithelia was 5.90±1.37 (mean ± s.d.). In benign tissues, the c-kit proto-oncogene product was detected heterogeneously with
a reduced IRS (4.05±1.82). In primary breast cancer tissues, the expression of the c-kit proto-oncogene product was often
deleted and the average IRS (0.90±1.73) was significantly reduced compared to those of the normal breast tissues or benign
breast disease tissues, but no significant difference was shown between the breast cancer groups. The c-kit proto-oncogene
product may correlate with growth control or the differentiation of normal breast epithelium. This result suggests that the
loss of expression of this protein might correlate with malignant breast cancer progression, but it is most likely involved
at an early stage of human breast cancer development.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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Keywords: | breast cancer c-kit proto-oncogene immunohistochemistry immunoreactive score malignant transformation |
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