| 丁胱亚磺酰亚胺对胶质瘤细胞GSH修饰作用的实验研究 |
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| 引用本文： | 江澄川,仝海波. 丁胱亚磺酰亚胺对胶质瘤细胞GSH修饰作用的实验研究[J]. 中国临床神经科学, 1997, 5(4): 187-190 |
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| 作者姓名： | 江澄川 仝海波 |
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| 作者单位： | 上海医科大学华山医院神经外科 200040(江澄川，唐镇生)，上海医科大学华山医院神经外科 博士生200040(仝海波，高翔)，上海医科大学放射医学研究所 200032(金一尊)，上海医科大学华山医院神经外科 博士生200040(田新华) |
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| 摘 要： | 利用体外培养的胶质瘤细胞株及裸小鼠移植瘤模型,研究了巯基修饰剂丁胱亚磺酰亚胺(BSO)对其谷胱甘肽(GSH)含量的影响。结果表明:无论是离体还是整体用药,BSO均能降低胶质瘤细胞的GSH含量。
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| 关 键 词： | 丁胱亚磺酰亚胺 谷胱甘肽 胶质瘤 |
Effects of BSO on GSH Contents in Glioma Cells |
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| Jiang Cheng-Chuan,Tang Zhen-Sheng,et al. Effects of BSO on GSH Contents in Glioma Cells[J]. Chinese Journal of Clinical Neurosciences, 1997, 5(4): 187-190 |
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| Authors: | Jiang Cheng-Chuan Tang Zhen-Sheng et al |
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| Affiliation: | Jiang Cheng-Chuan,Tang Zhen-Sheng,et alDepartment of Neurosurgery,Huashan Hospital,Institute of Radiology,Shanghai Medical University,Shanghai 200040 |
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| Abstract: | The effects of thiol modifier BSO on glioma cells were studied in the cultured gliomacells line and glioma bearing nudemouse. The results showed that BSO depleted intracellularGSH contents of glioma cells in vitro and in vivo. |
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| Keywords: | buthionine sulfoximine Glutathione Glioma |
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