| 卡介菌多糖核酸和死卡介菌对环磷酰胺免疫抑制作用的影响 |
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| 引用本文： | 罗秋平,谭礼智,王慧. 卡介菌多糖核酸和死卡介菌对环磷酰胺免疫抑制作用的影响[J]. 中南大学学报(医学版), 1996, 0(4) |
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| 作者姓名： | 罗秋平 谭礼智 王慧 |
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| 作者单位： | 湘雅医院呼吸内科，浙江医科大学 |
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| 摘 要： | 通过测定特异性抗体、淋巴细胞转化和巨噬细胞（ＭΦ）吞噬率，观察卡介菌多糖核酸（ＢＣＧ－ＰＳＮ）和死卡介菌（死卡）对抗环磷酰胺（ＣＴＸ）免疫抑制的作用。结果显示：ＢＣＧ－ＰＳＮ和死卡能增加小鼠有核脾细胞和腹腔细胞数、促进Ｔ淋巴细胞转化、促进血凝抑制抗体产生和增强ＭΦ的吞噬功能。ＣＴＸ对上述免疫细胞均有不同程度的抑制作用，尤对Ｂ细胞产生抗体的抑制作用最强。ＢＣＧ－ＰＳＮ和死卡对ＣＴＸ的免疫抑制有不同程度的保护作用，尤对ＭΦ吞噬功能保护力最强。结果提示，ＢＣＧ－ＰＳＮ可望用于临床使用ＣＴＸ的病人以增强免疫力。
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| 关 键 词： | 卡介菌多糖核酸；死卡介菌；环磷酰胺；T淋巴细胞；脾；巨噬细胞 |
THE EFFECTS OF BCG-POLYSACCHARIDE NUCLEIC ACIDFRACTION AND HEAT-KILLED BCG ON IMMUNOSUPPRESSION INDUCED BY CYCLOPHOSPHAMIDE |
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| Luo Qiuping,Tang Lizhi. THE EFFECTS OF BCG-POLYSACCHARIDE NUCLEIC ACIDFRACTION AND HEAT-KILLED BCG ON IMMUNOSUPPRESSION INDUCED BY CYCLOPHOSPHAMIDE[J]. Journal of Central South University. Medical sciences, 1996, 0(4) |
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| Authors: | Luo Qiuping Tang Lizhi |
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| Abstract: | he effects of BCG-polysaccharide nucleic acid fraction(BCG-PSN)and heat-killed BCGon immunosuppression induced by cyclophosphamide were studied.BCG-PSN and heat-killedBCG were found to be capable of increasing the number of splenic cells and macrophages and ofenhancing the function of splenic T cell,B cell and macrophage in mice. Cyclophosphamide wascapable of inhibiting the function of T cell,B cell and macrophage especially on the B cell.BCG-PSN and heat-killed BCG were capable of resisting immunospuppression induced by cyclophos-phamide to a certain extent. |
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| Keywords: | BCG-polysaccharide nucleic acid Heat-killed BCG cyclophosphamide splenic T cell Macrophage |
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