| 坐骨神经损伤后脊髓前角运动神经元死亡性质的探讨 |
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| 引用本文： | 尹方明,余国海,胡耀民,刘大庸.坐骨神经损伤后脊髓前角运动神经元死亡性质的探讨[J].第一军医大学分校学报,1998(2). |
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| 作者姓名： | 尹方明 余国海 胡耀民 刘大庸 |
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| 作者单位： | 解放军广州医学高等专科学校外科学教研室!广州510315(尹方明，余国海)，解放军第一军医大学解剖学教研室!广州510515(胡耀民，刘大庸) |
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| 基金项目： | 国家自然科学基金 No.39470365 |
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| 摘 要： | 目的:研究大鼠坐骨神经损伤后,脊髓前角运动神经元的死亡性质,以便加以保护,促进神经损伤后运动功能的恢复。方法:切断大鼠右侧坐骨神经,再原位吻合,于术后不同时间取L_4～L_6节段脊髓,作石蜡切片,通过H·E染色和Hoechst33258染色,光镜下分别观察前角运动神经元胞体的形态学变化特征;作超薄切片,电镜下观察前角运动神经元胞体超微结构的变化规律。结果:光镜下,右侧脊髓前角运动神经元胞体尼氏体和细胞核染色质浓缩;电镜下,细胞膜内陷,将细胞分割成凋亡小体,然后裂解,细胞体消失;而左侧前角运动神经元胞体均一、无变化。结论:坐骨神经损伤后,脊髓前角运动神经元有死亡,死亡性质是细胞凋亡。
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| 关 键 词： | 神经损伤 坐骨神经 脊髓前角运动神经元 细胞凋亡 |
The dead character of spine cord motoneurons after sciatic nerve injury |
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| Yin Fangming,Yu Guohai,Hu Yaomin,et al..The dead character of spine cord motoneurons after sciatic nerve injury[J].Journal of Branch Campus of the First Military Medical University,1998(2). |
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| Authors: | Yin Fangming Yu Guohai Hu Yaomin |
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| Abstract: | Functional restoration of a peripheral nerve following axotomy is unsatisfactoiy and axotomy-inducedneuronal cell death is believed to be one of the main reasons. Nerve growth factor(NGF) can protect spinal cordmotoncurons from axotomy-induced cell death. The character of the cell death is undefmite.The study demonstrates that the neuronal cell death is apoptosis after rat sciatic nerve injury. |
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| Keywords: | nerve injury sciatic nerve spinal cord motoneuron apoptosis |
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