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| 原癌基因C-erbB-2蛋白和PCNA在乳腺导管浸润癌中的表达及意义 | |
| 引用本文： | 王丽萍,张元德,张俊格,陈东,陈爱军,王晓明,申丽娟.原癌基因C-erbB-2蛋白和PCNA在乳腺导管浸润癌中的表达及意义[J].吉林大学学报(医学版),2000,26(5):476-478. |
| 作者姓名： | 王丽萍 张元德 张俊格 陈东 陈爱军 王晓明 申丽娟 |
| 作者单位： | 1. 张俊格第一临床学院病理科吉林长春 130021 2. 基础医学院组织学与胚胎学教研室 3. 吉林省东丰县医院病理科 |
| 基金项目： | 吉林省科技厅科研项目;970565-4; |
| 摘 要： | 目的 :检测原癌基因 C- erb B- 2蛋白和增殖细胞核抗原 (PCNA)在乳腺导管浸润癌中的表达及意义。方法 :对石蜡切片标本进行免疫组化染色。结果 :C- erb B- 2和 PCNA在乳腺导管浸润癌中阳性率为 74.3%和 68.6% ,二者表达与癌组织大小及分化程度呈正相关 (P<0 .0 5) ,与年龄、雌激素受体水平和生存期呈负相关 (P<0 .0 5)。与淋巴结有无转移无关 (P>0 .0 5)。结论 :C- erb B- 2和 PCNA过表达者预后不好、生存期短 ,尤其二者同时表达者预后更差。C- erb B- 2和 PCNA可作为判定乳腺导管浸润癌的恶性程度及预后的有效指标。 |
| 关 键 词： | 乳腺导管浸润癌 免疫组织化学 原癌基因蛋白C-erbB-2 增殖细胞核抗原 |
| 文章编号： | 0253-3707(2000)05-0476-03 |
| 修稿时间： | 1999年11月5日 |
Expression of oncoprotein C-erbB-2 and PCNA in invasive ductal carcinoma and their clinical significance |
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| Wang Liping ,Chen Dong ,Chen Aijun ,Zhang Yuande ,Zhang Junge ,Wang Xiaoming ,Shen Lijuan.Expression of oncoprotein C-erbB-2 and PCNA in invasive ductal carcinoma and their clinical significance[J].Journal of Jilin University: Med Ed,2000,26(5):476-478. | |
| Authors: | Wang Liping Chen Dong Chen Aijun Zhang Yuande Zhang Junge Wang Xiaoming Shen Lijuan |
| Institution: | Wang Liping 1,Chen Dong 2,Chen Aijun 2,Zhang Yuande 1,Zhang Junge 1,Wang Xiaoming 2,Shen Lijuan * |
| Abstract: | ? Objective:To examine the expressions of C-erbB-2 and PCNA in invasive ductal carcinoma and their clinical significance.Methods:Thirty-five cases of paraffin-embedded specimens of invasive ductal carcinoma were studied by immunohistochemical study.Results:The positive rates of C-erbB-2 and PCNA were 74.3% and 68.6% respectively.The expressions of C-erbB-2 and PCNA were closely correlated with tumor size and histological grading ( P <0 05);they were negatively correlated with the age,the level of estrogen receptor and the survival ducration ( P <0 05).There was no relationship between C-erbB-2,PCNA expression and lymph node metastases.Conclusion:The results suggest that the over-expressions of C-erbB-2 and PCNA show a poor prognosis and short survial ducration.C-erbB-2 and PCNA may be important markers in reflecting malignant differentiation grading and progenosis of invasive ductal carcinoma. 〔 |
| Keywords: | ? invasive ductal carcinoma immunohistochemistry oncoprotein C-erbB-2 proliferating cell nuclear antigen (PCNA) |
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