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商陆皂苷甲对哮喘小鼠气道炎症的缓解作用及对肺组织中IL-6和STAT3表达水平的影响
引用本文:王静,徐畅,宋艺兰,王重阳,姜京植,李良昌,延光海,苏立明. 商陆皂苷甲对哮喘小鼠气道炎症的缓解作用及对肺组织中IL-6和STAT3表达水平的影响[J]. 吉林大学学报(医学版), 2022, 48(2): 299-307. DOI: 10.13481/j.1671-587X.20220205
作者姓名:王静  徐畅  宋艺兰  王重阳  姜京植  李良昌  延光海  苏立明
作者单位:延边大学 吉林省过敏性常见疾病免疫与靶向研究重点实验室,吉林 延吉 133002
延边大学 附属医院儿科,吉林 延吉 133002
延边大学医学院解剖学教研室,吉林 延吉 133002
摘    要:目的:探讨商陆皂苷甲(EsA)对卵清蛋白(OVA)诱导哮喘小鼠气道炎症的药理作用,并阐明其作用机制.方法:40只清洁级BALB/c雌性小鼠随机分为空白对照组、OVA组、低剂量EsA组和高剂量EsA组,每组10只;除空白对照组外,其他组小鼠用腹腔注射致敏,分别在第1、7和14天致敏,从第21天开始采用1%OVA激发,每1...

关 键 词:商陆皂苷甲  哮喘  白细胞介素6  信号传导及转录激活蛋白-3
收稿时间:2021-09-08

Alleviation of esculentoside A on airway inflammation of asthmatic mice and its effect on expression levels of IL-6 and STAT3 in lung tissue
WANG Jing,XU Chang,SONG Yilan,WANG Chongyang,JIANG Jingzhi,LI Liangchang,YAN Guanghai,SU Liming. Alleviation of esculentoside A on airway inflammation of asthmatic mice and its effect on expression levels of IL-6 and STAT3 in lung tissue[J]. Journal of Jilin University: Med Ed, 2022, 48(2): 299-307. DOI: 10.13481/j.1671-587X.20220205
Authors:WANG Jing  XU Chang  SONG Yilan  WANG Chongyang  JIANG Jingzhi  LI Liangchang  YAN Guanghai  SU Liming
Affiliation:Key Laboratory of Immunization and Targeting Research on Common Allergic Diseases of Jilin Province,Yanbian University,Yanji 133002,China
Department of Pediatrics,Affiliated Hospital,Yanbian University,Yanji 133002 China
Department of Anatomy,School of Medicine,Yanbian University,Yanji 133002,China
Abstract:ObjectiveTo explore the pharmacological effect of esculentoside A (EsA) on the ovalbumin (OVA)-induced airway inflammation in the asthmatic mice, and to clarify its mechanism of action.
Keywords:
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