在体-离体生物感受细胞模型在毒理学评价中的应用进展

在体-离体生物感受细胞模型采用在体暴露评估、离体结局分析以及系统环境关键组分筛选的方法，评估环境污染物通过影响机体内环境稳态而导致的健康效应和毒作用机制。该模型整合了人群现场的真实暴露与实验室细胞分子机制研究，结合了体外和体内模型的优势，弥补了单一的毒理学评价模型的不足，从宏观人群研究和微观机制探索之间的介尺度层面，为...

Advanced progress of ex vivo biosensor assay in toxicological evaluation

The ex vivo biosensor assay is developed to assess the health effects and toxicological mechanism of environmental pollutants with internal environment homeostasis changes by integrating the in vivo exposure evaluation,in vitro outcomes analysis,and systematic environment component screening.This toxicology testing model combines the real-world exposure of people in the field and the study of molecular mechanism exploration in lab experiments to overcome the shortcomings of a single toxicology method.It provides a new technique and perspective for toxicity testing and risk assessment in mesoscale between macroscopic population study and microscopic mechanism exploration.