代谢正常型肥胖的新认识及其研究机遇

肥胖悖论和代谢正常型肥胖正在受到挑战,越来越多的研究就代谢正常型肥胖的潜在机制及其预后价值产生争议。研究代谢正常型肥胖有利于阐明肥胖悖论及不同程度肥胖对人群危害的潜在机制。本研究从循证医学的角度,结合国内外相关文献,就代谢正常型肥胖的新认识、生活方式因素以及脂肪因子对代谢正常型肥胖的影响、代谢正常型肥胖研究的新机遇进行综述,以期探究代谢健康型肥胖可否长期保持并逐步降低体重,用以改善人群心血管病疾病的发病和死亡情况,从而达到相关疾病一级预防的目的。

New understanding and research opportunities of metabolically healthy obesity

The paradox of obesity and metabolically healthy obesity are being challenged.More and more studies have disputed the potential mechanism and prognostic value of metabolically healthy obesity.The study of metabolically healthy obesity is helpful to clarify the potential causes of obesity paradox and the potential mechanism of different degrees of obesity harm to the population.From the perspective of evidence-based medicine,combined with the relevant literature at home and abroad,this study reviewed the new understanding of metabolically healthy obesity,lifestyle factors,the impact of fat factors on metabolically healthy obesity,and the new opportunities of metabolically healthy obesity research,in order to explore whether metabolically healthy obesity can maintain and gradually reduce weight for a long time,so as to improve cardiovascular disease In order to achieve the purpose of primary prevention of related diseases.