右美托咪定不同负荷量对消化道肿瘤患者术后肠功能恢复的影响

目的:探讨右美托咪定不同负荷量对消化道肿瘤患者术后肠功能恢复的影响.方法:选取2019年2月至2021年3月该院收治的择期行消化道肿瘤手术的患者108例,按随机数字表法分成A、B和C组,每组36例.A、B组患者于麻醉诱导前10 min分别静脉泵入右美托咪定负荷量0.5、1.0μg/kg,术中均以0.5μg/(kg·h)...

Effects of Different Loading Doses of Dexmedetomidine on Postoperative Recovery of Intestinal Function in Patients with Gastrointestinal Tumor

OBJECTIVE:To probe into the effects of different loading doses of dexmedetomidine on postoperative recovery of intestinal function in patients with gastrointestinal tumor.METHODS:Totally 108 patients undergoing gastrointestinal tumor surgery in this hospital from Feb.2019 to Mar.2021 were extracted to be divided into the group A,B and C via the random number table,with 36 patients in each group.In group A and B,0.5μg/kg and 1.0μg/kg of dexmedetomidine were pumped intravenously 10 min before anesthesia induction,and 0.5μg/(kg·h)of dexmedetomidine was infused continuously until 10 min before the end of skin suture.In group C,the same volume of 0.9%sodium chloride injection was pumped intravenously.Three groups were given anesthesia induction and maintenance in the same way.The mean arterial pressure(MAP)and heart rate(HR)were recorded before dexmedetomidine pumping(T₀),after endotracheal intubation(T₁),at withdrawal of dexmedetomidine(T₂),immediately after extubation(T₃),and 30 min after extubation(T₄)in three groups were recorded,the serum levels of cortisol(Cor)and norepinephrine(NE)were detected after collecting the blood samples at the above time points,the time of exhaust and defecation was recorded,and the incidence of postoperative anesthesia related complications was observed.RESULTS:From T₁to T₄,the MAP,HR,serum Cor and NE levels in group A and B were significantly lower than those in group C,and the MAP,HR,serum Cor and NE levels in group B were significantly lower than those in group A,with statistically significant differences(P<0.05).The time of exhaust and defecation in group A and B was significantly shorter than that in group C,and the time of exhaust and defecation in group B was significantly shorter than that in group A,with statistically significant differences(P<0.05).The incidence of agitation during extubation in group B was significantly lower than that in group C,with statistically significant differences(P<0.05).CONCLUSIONS:The application of dexmedetomidine during surgery in patients with gastrointestinal tumor can effectively control the hemodynamics and stress responses,significantly reduce the incidence of agitation during extubation,and shorten the recovery time of postoperative intestinal function;the effect of continuous infusion of dexmedetomidine at 0.5μg/(kg·h)after 1.0μg/kg loading dose of intravenous pumping is better.