99例注射用替加环素使用合理性分析

目的:探讨临床-康复双路径管理三级康复医院住院患者注射用替加环素的使用合理性,为临床合理用药提供参考.方法:对2018年1月至2021年5月该院康复药学中心会诊的99例应用注射用替加环素治疗的患者病历资料进行回顾性分析,内容包括患者的基本资料、病原学检查及药物敏感试验、用药合理性、疗效以及不良反应发生情况等.结果:该院...

Application Rationality of Tigecycline for Injection in 99 Patients

OBJECTIVE:To probe into the application rationality of tigecycline for injection in inpatients in a tertiary rehabilitation hospital based on clinical-rehabilitation dual pathway management,so as to provide references for clinical rational medication.METHODS:Retrospectively analysis was conducted on the medical records of 99 patients using tigecycline for injection who were consulted at rehabilitation pharmacy center in this hospital from Jan.2018 to May 2021,patients’general information,pathogenic examination,drug sensitivity test,medication rationality,clinical efficacy and incidence of adverse drug reactions were analyzed.RESULTS:The patients using tigecycline for injection in this hospital was mostly elderly male,and the overall number of patients was increasing year by year.Among the 99 patients,84 cases underwent pathogenic examination,and the delivery specimens were mainly sputum;totally 132 case-times of pathogenic bacteria were detected,mainly were Klebsiella pneumoniae,Acinetobacter baumannii and Pseudomonas aeruginosa,all of which showed high drug resistance;the clinical effective rate was 78.79%(78 cases),and the incidence of adverse drug reactions was 5.05%(5 cases);the usage and dosage,route of administration and drug combination were all reasonable;2 cases(2.02%)were basically reasonable,mainly for empirical medication;20 cases(20.20%)were irrational medication,mainly for unreasonable indications and medication regimen.CONCLUSIONS:The clinical treatment effect of tigecycline for injection is good,with few adverse drug reactions.The main types of irrational drug application in this hospital are improper indications and medication regimen,the clinic should strengthen drug management,continuously carry out training on rational application of antibiotics to avoid drug abuse and improve the level of clinical rational drug application.