新愿景下毒性测试方法的发展与变革

随着全球化学品产量增加, 人群暴露及健康风险加重, 对化学品毒性测试和安全性评价提出更高的要求。21世纪毒性测试愿景和策略的提出大力推动了毒性测试的变革。新时代毒性测试通过运用新模型、新方法和新策略, 结合交叉学科和高新技术优势, 得到了长足发展。提高化学物毒性测试效率的同时, 也实现了更全面、多层次、高质量的数据获取和毒性评价, 为毒作用模式、毒作用机制和毒性通路的探索提供有力支持。本期重点号围绕当前毒性测试替代新方法, 邀请多位学者对高内涵分析、3D细胞培养技术、Ex vivo试验、单细胞测序、斑马鱼实验方法进行介绍和阐述, 以期为推动我国化学物毒性测试评估实现跨越发展开拓崭新思路。

Advances in alternative methods upon the vision for toxicity testing in the 21st century

With the increase of global chemical production and the aggravation of population exposure and health risks,higher requirements are put forward for chemical toxicity testing and safety evaluation.‘Toxicity testing in the 21st century:a vision and a strategy’has greatly promoted the reform of toxicity testing.Toxicity testing in the new era has made great progress by using new models,new methods and new strategies,combined with interdisciplinary and high-tech advantages.While improving the efficiency of chemical toxicity testing,it also realizes more comprehensive,multi-level and high-quality data acquisition and toxicity evaluation,which provides strong support for the exploration of toxicity mode,toxicity mechanism and toxicity pathway.Focusing on the current alternative new methods of toxicity testing,this issue invites many scholars to introduce and summarize high-content analysis,three-dimensional(3D)cell culture technology,Ex vivo test,single cell sequencing and zebrafish experimental methods,in order to promote the leapfrog development of chemical toxicity testing and evaluation in China.