| 细胞自噬促进血管平滑肌细胞向合成表型转化的作用与机制 |
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| 引用本文： | 李彩娟,赵自刚. 细胞自噬促进血管平滑肌细胞向合成表型转化的作用与机制[J]. 中国病理生理杂志, 2022, 0(2): 358-363 |
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| 作者姓名： | 李彩娟 赵自刚 |
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| 作者单位： | 河北北方学院微循环研究所 |
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| 基金项目： | 河北省自然科学基金资助项目(No.H2020405012)。 |
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| 摘 要： | 血管平滑肌细胞(vascular smooth muscle cells, VSMCs)具有两种不同表型,即分化表型(收缩表型)和去分化表型(合成表型).VSMCs来自中胚层,由低分化合成表型发育至高分化收缩表型.在成熟动脉,生理状态下的VSMCs处于分化静止状态,稳定在具有成年特性的收缩表型,主要维持血管的收缩功能[...
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| 关 键 词： | 自噬 血管平滑肌细胞 表型转化 |
Role and mechanism of autophagy in promoting transformation to synthetic phenotype of vascular smooth muscle cells |
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| LI Cai-juan,ZHAO Zi-gang. Role and mechanism of autophagy in promoting transformation to synthetic phenotype of vascular smooth muscle cells[J]. Chinese Journal of Pathophysiology, 2022, 0(2): 358-363 |
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| Authors: | LI Cai-juan ZHAO Zi-gang |
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| Affiliation: | (Institute of Microcirculation,Hebei North University,Zhangjiakou 075000,China) |
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| Abstract: | The important role of autophagy and phenotypic transformation in vascular smooth muscle cells(VSMCs)during cardiovascular diseases has received extensive attention. Autophagy of VSMCs is regulated by various signaling pathways including PI3 K/Akt/mTOR,AMPK,NF-κB,and MAPKs. More importantly,PI3 K/Akt/mTOR,AMPK and NF-κB pathways participate in the autophagy-regulated phenotypic transformation of VSMCs. Therefore,accurate understanding of the relationship between phenotypic transformation and autophagy,and the mechanism of autophagyinduced phenotypic transformation of VSMCs,may provide new insights into the prevention and treatment of vasomotor diseases. |
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| Keywords: | Autophagy Vascular smooth muscle cells Phenotypic transformation |
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