加味五子衍宗颗粒治疗轻度认知障碍的随访研究

目的:观察轻度认知障碍(mild cognitive impairment,MCI)患者服用加味五子衍宗颗粒3个月及停药1年的疗效及转归。方法:参照目前国际公认的MCI诊断标准,筛选出36例MCI患者,采用随机双盲分组,分为加味五子衍宗颗粒治疗组(简称治疗组18例)和安慰剂对照组(简称对照组18例),服药3个月,观察用药前后记忆功能及药物安全性,随访1年。另选20名健康人为正常对照组(简称正常组)。结果:MCI患者的记忆商(MQ)较健康人明显降低(P<0.01)。用药后,治疗组的MQ较其用药前明显提高(P<0.01),且较对照组治疗前后MQ的差值有明显提高(P<0.05)。随访1年,服药组无1例发生不良反应,停药1年治疗组的MQ仍较其用药前有明显提高(P<0.01)。对照组有2例MCI患者转化为痴呆。结论:加味五子衍宗颗粒能改善MCI患者的记忆功能,且有防治MCI向痴呆发展的作用。

Follow-up Study on Treatment of Mild Cognitive Impairment by Modified Wuzi Yanzong Granule

Objective:To observe the effect of mild cognitive impairment(MCI)on Treatment by Modified Wuzi Yanzong Granule(MWYG) for 3 months and after drug withdrawal 1 year.Methods: According to the international accepted diagnostic criteria,36 MCI patients were selected and randomly assigned two groups equally,the treated group treated with MWYG(18 cases) and the control group with placebo(18 cases),with a course of 3 months for both groups and followed up for 1 year. Besides,20 healthy subjects were selected as the normal group.The changes of memory ability and safety before and after treating were observed.Results: Memory quotient(MQ) was significantly lower in MCI patients than in healthy subjects(P<0.01).After treatment it increased in the treated group as compared with that before treatment(P<0.01),and the inerement was higher the that in the control group(P<0.05).After drug withdrawal 1 year,there was still increase in MQ(P<0.01) than that before treatment in MWYG group,no adverse reaction was found in two groups,and there were two cases of the control group developed into dementia in the elderly.Conclusion: MWYG could improve MCI patients' memory ability and could prevent from MCI into dementia in the elderly.