Serum 25 (OH) D and 24,25 (OH)2 D levels in childhood nephrosis under different therapeutic regimens of steroid administration |
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| Authors: | K. Kano T. Suda |
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| Affiliation: | (1) Department of Pediatrics, Tokyo Medical and Dental University School of Medicine, 5-45, Yushima 1-chome Bunkyo-ku, 113 Tokyo, Japan;(2) Department of Biochemistry, School of Dentistry, Showa University, 1-5-8, Hatanodai Shinagawa-ku, Tokyo, Japan |
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| Abstract: | The effect of prednisone therapy on serum levels of 25-hydroxyvitamin D [25(OH)D] and 24,25-dihydroxyvitamin D [24,25(OH)2D] was investigated in 16 children with nephrotic syndrome. These serum levels were significantly lower in patients before prednisone therapy than in age- and seasonmatched normal subjects. Patients receiving daily prednisone therapy had lower serum levels than those receiving alternateday prednisone therapy at the time when the total amounts of the steroid administered attained 1,500 or 2,000 mg/m2 of body surface area. Daily doses of 40 mg/m2 of prednisone for 3 days caused a significant decrease in serum 25(OH)D levels. Withdrawal of the steroid for 4 consecutive days was followed by a significant recovery of the serum levels.These results suggest that alternate-day prednisone therapy rather than daily treatment should be used in clinical practice to help maintain normal vitamin D metabolism.Abbreviations 25(OH)D 25-hydroxyvitamin D - 24,25(OH)2D 24,25-dihydroxyvitamin D |
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| Keywords: | 25-Hydroxyvitamin D 24,25-Dihydroxyvitamin D Steroid-induced bone complications Nephrotic syndrome Relapser |
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