High-resolution array CGH clarifies events occurring on 8p in carcinogenesis |
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| Authors: | Susanna L Cooke Jessica CM Pole Suet-Feung Chin Ian O Ellis Carlos Caldas Paul AW Edwards |
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| Affiliation: | (1) Department of Pathology and Hutchison/MRC Research Centre, University of Cambridge, Cambridge, UK;(2) CRUK Cambridge Research Institute and Department of Oncology, University of Cambridge, Cambridge, UK;(3) Department of Histopathology, Nottingham City Hospital NHS Trust and University of Nottingham, Nottingham, UK |
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| Abstract: | Background Rearrangement of the short arm of chromosome 8 (8p) is very common in epithelial cancers such as breast cancer. Usually there is an unbalanced translocation breakpoint in 8p12 (29.7 Mb – 38.5 Mb) with loss of distal 8p, sometimes with proximal amplification of 8p11-12. Rearrangements in 8p11-12 have been investigated using high-resolution array CGH, but the first 30 Mb of 8p are less well characterised, although this region contains several proposed tumour suppressor genes. |
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