维持性血透者CRP与心血管事件的相关性分析

目的:探讨维持性血液透析患者C-反应蛋白(CRP)与心血管事件的关系.方法:选取维持性血液透析患者120例,采用免疫透射比浊法定期检测血脂、脂蛋白Lp(α)]、血清白蛋白(ALB)、血肌酐(Scr)、血尿素氮(BUN)与超敏C-反应蛋白(hs-CRP),以起始hs-CRP正常参考值3 mg/L为分界点分为CRP正常组(54例)与CRP升高组(66例),观察2组患者心血管事件的发生率与病死率,分析维持性血液透析患者C-反应蛋白与心血管事件的关系.结果:CRP升高组心血管事件的发生率和病死率显著高于CRP正常组(P＜0.05).结论:维持性血液透析患者存在慢性微炎症状态,CRP升高是心血管事件的危险因素.

Correlation Analysis of Cardiovascular Event with High Sensitive C Reactive Protein in Hemodialysis Patients

Objective:To explore the relationship of C reactive protein and cardiovascular events in maintenance hemodialysis patients.Methods:120 cases of maintained hemodialysis patients,had immune turbidimetry periodic detections of lipid,lipoprotein,serum albumin(ALB),serum creatinine(Scr),blood urea nitrogen(BUN) and high sensitive C reactive protein(hs-CRP),hs-CRP 3 mg/L was as the normal reference value of the cut-off point.CRP normal group 54 cases,elevated CRP group 66 cases,in two groups the incidence of cardiovascular events and mortality rate were observed;the relationship of C reactive protein with cardiovascular events in maintenance hemodialysis patients were analysed.Results:in the high CRP group the incidence of cardiovascular events and mortality rates were significantly higher than those in normal CRP group(P<0.05).Conclusion:Hemodialysis patients have chronic inflammation state,C reactive protein is a risk factor for cardiovascular events.