2010—2011年度某医院葡萄球菌耐药性分析

目的:调查分析2010-2011年度某医院临床分离的2 904株葡萄球菌分布及其对常用抗菌药物的耐药性.方法:采用VITEK全自动细菌鉴定仪及纸片扩散法(K-B法)进行鉴定及药物敏感性分析.结果:耐甲氧西林金黄色葡萄球菌(MRSA)检出率在2010年及2011年分别占54.30%及66.85%;2 904株葡萄球菌对利奈唑胺均敏感,2011年发现少量对万古霉素耐药的葡萄球菌.2010年与2011年葡萄球菌对四环素、大环内酯类、复方新诺明等的耐药性均未见明显增加,复方新诺明对金黄色葡萄球菌敏感性相对较高.结论:MRSA检出率2011年明显高于2010年(P＜0.05).葡萄球菌耐药性需加强监测,并采取有效控制措施.

Surveillance of Bacterial Resistance of Staphylococcus from 2010-2011

Objective: To investigate the clinical pathogen resistance profile after using antimicrobial agents in 2904 stains of Staphylococcus from 2010-2011.Methods: A total of 2904 strains were identified with a Vitek-2 mcrobiology analyzer,and antimicrobial susceptibility testing was performed by Kirby-Bauer disk diffusion.Results: Detection rates of MRSA in 2010 and 2011 were 54.30% and 66.85%,respectively.All 2904 stains of Staphylococcus were sensitive to linezolid.A few strains of Staphylococcus were showed resistant to vancomycin in 2011.Drug resistense of Staphylococcus to tetracycline,macrolides and cotrimoxazole were not increased significantly in 2010 and 2011.Sensitive rates of staphylococcus to cotrimoxazole was high relatively.Conclusion: Detection rates of MRSA in 2011 was higher than in 2010(P < 0.05).Surveillance of antimicrobial agents to Staphylococcus is very important,and effective control measures are also necessary.