多种肿瘤标志物在胃癌诊断中的价值

目的:探讨多项肿瘤标志物在胃癌分期诊断中的应用价值.方法:采用电化学发光分析法分别对经病理检查证实的60例各期胃癌患者和60例胃良性病变(对照Ⅰ组)与60例健康体检者(对照Ⅱ组)的血清CA72 -4、CEA、CA242、CA19 -9这4项指标进行比较.结果:胃良性病变患者与健康体检者的CA72 -4、CEA、CA242、CA19 -9指标相比无显著性差异(P＞0.05).胃癌Ⅰ期、Ⅱ期患者中CA72 -4、CEA、CA242、CA19 -9水平与对照2组比较无显著性差异(P＞0.05),Ⅲ期、Ⅳ期的CA72 -4、CEA、CA242、CA19 -9水平却明显高于对照2组,有显著性差异(P＜0.01).同时联合检测胃癌Ⅰ期、Ⅱ期、Ⅲ期患者的阳性率明显好于单项检测(P＜0.01).结论:血清CA72 -4、CEA、CA242、CA19 -9的表达与肿瘤的临床分期状况有关,胃癌越处于晚期,肿瘤标志物阳性率越高.

The Comparing Analysis of Multiple Tumor Markers and Pathological Examination in Diagnosis of Gastric Cancer

Objective:To explore the applying value of various tumor markers in diagnosis of Gastric cancer.Methods:The serum CA72-4、CEA、CA242 and CA19-9 in the 60 patients with various gastric cancer,60 patients with benign gastric lesions(the control Ⅰ group) and 60 cases of healthy people(the control Ⅱ group) were detected by the electrochemical luminescence analyzed statistically.Results:CA72-4、CEA、CA242 and CA19-9 levels in The gastric cancer Ⅰ,Ⅱcompared with in the control group were not significant difference(P>0.05),But the CA72-4、CEA、CA242 and CA19-9 levels in the gastric cancer Ⅲ,Ⅳ were significantly higher than other two control group,the difference was statistically significant(P<0.01).And combined detection of gastric cancer Ⅰ,Ⅱ,Ⅲ were significantly better than the single test(P<0.01).Conclusion:CA72-4、CEA、CA242 and CA19-9 expression are related to the clinical stage conditions,the more advanced Gastric cancer,the more of the tumor marker-positive rate.