特拉唑嗪及与双氯芬酸钠联合治疗CP/CPPS的研究

目的:比较单用特拉唑嗪与特拉唑嗪联合双氯芬酸钠治疗慢性前列腺炎/慢性骨盆疼痛综合征(CP/CPPS)的效果。方法:将106例CP/CPPS患者随机分为2组,A组予特拉唑嗪治疗(2 mg/d),B组予特拉唑嗪(2 mg/d)加双氯芬酸钠(25 mg/d)治疗。采用美国国立卫生研究所慢性前列腺炎症状评分(NIH-CPSI)、亚评分(疼痛及生活指数)及国际前列腺症状评分(IPSS)标准评价患者治疗8周后的效果。结果:2组治疗后的NIH-CPSI、亚评分及IPSS均明显减少,且2组之间评分无显著性差异。结论:特拉唑嗪单独治疗与联合双氯芬酸钠治疗CP/CPPS的效果相当。

The Research of Terazosin Hydrochloride Combined with Diclofenac Sodium in Treatment of CP / CPPS

Objective:To compare terazosin monotherapy with terazosin plus diclofenac in treatment of chronic prostatitis/chronic pelvic pain syndromes(CP/CPPS) following initial randomness.Methods:Patients(n=106) who were diagnosed with CP/CPPS were randomly assigned to treatment with terazosin at 2 mg(group A),terazosin at 2 mg plus diclofenac at 25 mg(group B) daily.National Institutes of Health-Chronic Prostatitis Symptom Index(NIH-CPSI),subscores and the International Prostate Symptom Score(IPSS) were used to evaluate 104 patients who were treated for 8 weeks(2 withdrew).Results:The two groups all showed statistically difference before and after treatment,decreased in NIH-CPSI score,subscore and IPSS(P<0.05).There were no statistically differences between the two groups.Conclusion:Terazosin monotherapy for 8 weeks is effective for treating patients with CP/CPPS same as with diclofenac.