| 室内常见气传真菌代谢提取物的遗传毒性研究 |
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| 引用本文： | 阚海东,宋伟民,蒋蓉芳.室内常见气传真菌代谢提取物的遗传毒性研究[J].中国公共卫生,2001,17(7):613-614. |
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| 作者姓名： | 阚海东 宋伟民 蒋蓉芳 |
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| 作者单位： | 上海医科大学公共卫生学院, |
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| 摘 要： | 目的 探讨室内常见气传真菌代谢提取物的致突变性。方法 分别采用以基因突变为测试终点的Ames试验、以DNA损伤为UDS试验及染色体损伤为终点的体外细胞微核试验，对其进行了系统研究。结果 Ames试验结果显示部分室内气传真菌代谢提取物是一种间接致突变物质，UDS试验结果表明其具有DNA损伤作用，体外细胞微核试验显示其具有染色体损失作用。结论 部分室内常见气传真菌代谢提取物具有一定的遗传毒性。
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| 关 键 词： | 室内真菌 遗传毒性 Ames试验 程序外DNA合成 真菌毒素 肿瘤 致癌性 细胞微核试验 |
| 文章编号： | 1001-0580(2001)07-0613-02 |
| 修稿时间： | 2000年7月18日 |
Study on the Genotoxicity of Culture Extracts of Indoor Airborne Fungal |
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| KAN Hai dong,et al..Study on the Genotoxicity of Culture Extracts of Indoor Airborne Fungal[J].Chinese Journal of Public Health,2001,17(7):613-614. |
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| Authors: | KAN Hai dong |
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| Institution: | KAN Hai dong,et al.Public Health School,Shanghai Medical University |
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| Abstract: | Objective To study the genotoxicity of fungal culture extracts.Mothods The tests include the Ames test to detect gene mutation,unscheduled DNA synthesis (UDS) assay to detect DNA damage and in vitro cellular micronucleus assay to detect chromosome damage.Results Ames test showed some fungal extracts are indirect mutagenesis,UDA assay revealed DNA damage effects of some fungal extracts,and in vitro micronucleus assay showed they could also cause chromosome damage.Conclusion The result suggested that some fungal culture extracts should have genotoxicity and potential carcinogenicity. |
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| Keywords: | indoor airborne fungi genotoxicity Ames test unscheduled assay cell micronucleus test |
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