| 迷迭香酸对MPP~+导致MES 23.5细胞损伤保护作用 |
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| 引用本文： | 杜婷婷,宋宁,谢俊霞,姜宏.迷迭香酸对MPP~+导致MES 23.5细胞损伤保护作用[J].青岛大学医学院学报,2010,46(3):193-195. |
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| 作者姓名： | 杜婷婷 宋宁 谢俊霞 姜宏 |
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| 作者单位： | 青岛大学国家生理学重点(培育)学科,山东,青岛,266071 |
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| 基金项目： | 山东省自然科学基金重点项目 |
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| 摘 要： | 目的观察迷迭香酸对1-甲基-4-苯基吡啶阳离子(MPP+)所致MES 23.5细胞损伤的保护作用。方法采用四甲基偶氮唑盐(MTT)检测方法,观察不同浓度的迷迭香酸对MPP+处理的MES 23.5细胞的保护作用。结果 10-9~10-6mol/L的迷迭香酸对MES 23.5细胞无毒性作用(F=0.581,P>0.05)。200μmol/L的MPP+可使细胞存活率降低(F=44.863,P<0.01),而应用10-9~10-6mol/L的迷迭香酸预孵育细胞后,能明显提高细胞的存活率(P<0.01)。结论迷迭香酸能拮抗MPP+对MES 23.5细胞的毒性作用,具有一定的神经保护作用。
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| 关 键 词： | 迷迭香酸 1-甲基-4-苯基吡啶 MES23.5细胞 |
NEUROPROTECTIVE EFFECT OF ROSMARINIC ACID ON 1-METHYL-4-PHENYLPYRIDINIUM INDUCED CYTOTOXICITY OF THE MES 23.5 CELLS |
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| DU TING-TING,SONG NING,XIE JUN-XIA,et al.NEUROPROTECTIVE EFFECT OF ROSMARINIC ACID ON 1-METHYL-4-PHENYLPYRIDINIUM INDUCED CYTOTOXICITY OF THE MES 23.5 CELLS[J].Acta Academiae Medicinae Qingdao Universitatis,2010,46(3):193-195. |
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| Authors: | DU TING-TING SONG NING XIE JUN-XIA |
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| Institution: | DU TING-TING,SONG NING,XIE JUN-XIA,et al (State Key Discipline: Physiology(in Incubation),Department of Physiology,Qingdao University,Qingdao 266071,China) |
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| Abstract: | Objective To investigate the neuroprotective effect of rosmarinic acid on 1-methyl-4-phenylpyridinium(MPP+)-induced damage of MES 23.5 cells. Methods MTT assay was used to observe the protection of rosmarinic acid,in different concentrations,on MPP+-treated MES 23.5 cell. Results Rosmarinic acid(10-9-10-6 mol/L) did not produce any toxic effect on MES 23.5 cells(F=0.581,P>0.05).The cell viability decreased when treated with 200 μmol/L MPP+(F=44.863,P<0.01).However,pretreatment with 10-9-10-6 mol/L rosmarinic acid significantly elevated the cell survival rate(P<0.01). Conclusion Rosmarinic acid can antagonize the toxic action of MPP+ on MES 23.5 cells,possessing a certain neuroprotective effect. |
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| Keywords: | rosmarinic acid 1-Methyl-4-phenylpyridinium MES 23 5 cells |
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