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扶肾胶囊防治肾小球高血液动力学损伤的机理
引用本文:王耀光,徐尧军,杨玉兰,李世明,陈婕,梅学仁,赵长城.扶肾胶囊防治肾小球高血液动力学损伤的机理[J].河南中医学院学报,2007,22(1):29-31.
作者姓名:王耀光  徐尧军  杨玉兰  李世明  陈婕  梅学仁  赵长城
作者单位:天津中医学院第一附属医院 天津300193(王耀光),天津中医学院第二附属医院 天津300150(徐尧军,杨玉兰,陈婕,赵长城),河北省邯郸钢铁有限公司职工医院 河北邯郸056001(李世明),国家医药管理局天津药物研究院药理室 天津300193(梅学仁)
摘    要:目的:研究具有温阳益阴、泻浊活血作用的扶肾胶囊对肾小球高血液动力学病理损伤的防治作用.方法:选取Wistar大鼠40只,雌雄各半,体重(100±15) g.造模方法参照Jane Boudet氏法改制.随机分为模型对照组、空白对照组、扶肾胶囊组.除空白对照组外,每组灌饲相应药物.给药时间60 d.结果:肾皮质电灼所致的大鼠慢性肾功能衰竭模型存在明显的肾小球高血液动力学病理损伤,表现为除Scr、BUN升高外,具备电灼肾宽、厚明显增加、肾小球局灶或节段性硬化.相间以肾小球代偿肥大,24 h尿蛋白排泄率亦显著增加等病理特点.而扶肾胶囊治疗组大鼠,其肾功能明显改善(Scr、BUN下降具统计学差异)的同时,24 h尿蛋白排泄率、肾小球总硬化率、毛细血管丛塌陷率、小球肥大率、平均肾小球直径和平均肾小球内细胞数均显著下降.结论:扶肾胶囊有防治慢性肾功能衰竭时存在的肾小球高血液动力学病理损伤的作用.

关 键 词:肾小球高血液动力学  慢性肾功能衰竭  大鼠  扶肾胶囊
文章编号:1672-6839(2007)01-0029-03
修稿时间:2006年9月25日

Mechanism of Invigorate the Kidney Capsules to Prevent and Cure High Glomerulus Hemodynamics Impairment
Wang Yaoguang,Xu Raojun,Yang Yulan,Li Shiming,Chen Jie,Mei Xueren,Zhao Changcheng.Mechanism of Invigorate the Kidney Capsules to Prevent and Cure High Glomerulus Hemodynamics Impairment[J].Journal of Henan University of Chinese Medicine,2007,22(1):29-31.
Authors:Wang Yaoguang  Xu Raojun  Yang Yulan  Li Shiming  Chen Jie  Mei Xueren  Zhao Changcheng
Abstract:Objective: To investigate the preventive and therapeutic effect of invigorate the kidney capsules on high glomerulus hemodynamics impairment. Method: 40 Wistar rats were randomly divided three groups as follow: control, model and treatment. Except control, model and treatment had been fed medicine for 60 days. Result: The model rats showed high glomerulus hemodynamics patho-impairment, wide and thick fulgerize kidney, focus or segmented sclerosis of glomerulus, large glomerulus and urine protein excretion rate to increase in 24 hours except higher Scr, higher BUN, but the treatment rats showed opposite to the model group. Conclusion: Invigorate the kidney capsules had the function to prevent and cure high glomerulus hemodynamics impairment when chronic renal failure.
Keywords:High glomerulus hemodynamics  Chronic renal failure  Rat  Invigorate the kidney capsules
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