| 非小细胞肺癌放疗前后血清肿瘤标记物的改变及其临床意义 |
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| 引用本文： | 张国云,周春宇,刘晓岚.非小细胞肺癌放疗前后血清肿瘤标记物的改变及其临床意义[J].中国实验诊断学,2011,15(5):851-852. |
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| 作者姓名： | 张国云 周春宇 刘晓岚 |
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| 作者单位： | 中国医科大学附属第四医院,放射治疗科,辽宁,沈阳110032 |
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| 摘 要： | 目的观察非小细胞肺癌（NSCLC）放疗前后血清CEA、CYFRA21-1、NSE的变化,探讨血清肿瘤标记物的改变能否用于评价放疗疗效。方法选取58例接受放射治疗的非小细胞肺癌病例（其中22例为局部晚期患者行胸部原发灶放疗,12例行骨转移放疗,24例行脑转移放疗）,所选病例放疗前肿瘤标记物均高于正常参考值,分别记录放疗前与放疗后血清CEA、NSE、CYFRA21-1的数值,并用Wilcoxon秩检验进行统计分析,以p〈0.05为有统计学意义。结果 22例胸部放疗患者放疗后血清CEA、NSE、CYFRA21-1水平较放疗前降低（P值分别为0.046,0.003,0.002）,12例骨转移患者放疗后血清CEA、NSE、CYFRA21-1水平较放疗前降低（P值分别为0.05,0.015,0.017）,24例肺癌脑转移患者放疗前后血清CEA、NSE、CYFRA21-1水平无统计学差异（P〉0.05）。结论血清CEA、CYFRA21-1、NSE水平可以用于非小细胞肺癌胸部放疗及骨转移放疗后的疗效评价。
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| 关 键 词： | 非小细胞肺癌 肿瘤标记物 放疗 |
The impact and clinical significance of radiotherapy on serum tumor markers in patients with non-small cell lung cancer |
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| ZHANG Guo-yun,ZHOU Chun-yu,LIU Xiao-lan.The impact and clinical significance of radiotherapy on serum tumor markers in patients with non-small cell lung cancer[J].Chinese Journal of Laboratory Diagnosis,2011,15(5):851-852. |
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| Authors: | ZHANG Guo-yun ZHOU Chun-yu LIU Xiao-lan |
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| Institution: | ZHANG Guo-yun,ZHOU Chun-yu,LIU Xiao-lan.(The Fourth Hospital of China Medical University,Shenyang 110032,China) |
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| Abstract: | Objective To observe the impact of radiotherapy on serum tumor marker such as CEA,NSE,CYFRA21-1 in patients with non-small cell lung cancer(NSCLC),Investigate whether the change of tumor maker can evaluate the effect of radiotherapy.Methods Fifty-eight NSCLC patients were treated with radiotherapy and tested serum TM(CEA,NSE,CYFRA21-1) before and after radiotherapy,tumor marker of all the cases were higher than normal reference values,record the value of TM before and after radiotherapy respectively.Results... |
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| Keywords: | non-small cell lung cancer tumor marker radiaion |
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