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| 水通道蛋白AQP1、AQP3在神经鞘瘤中的表达 | |
| 引用本文： | 乔颖,刘津,苏维恒,冯学超,何成彦. 水通道蛋白AQP1、AQP3在神经鞘瘤中的表达[J]. 中国实验诊断学, 2011, 15(4): 607-608 |
| 作者姓名： | 乔颖 刘津 苏维恒 冯学超 何成彦 |
| 作者单位： | 1. 东北师范大学膜通道实验室,吉林,长春130024 2. 海洋石油总医院 3. 吉林大学中日联谊医院,吉林,长春130033 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的检测水通道13、在人外周神经肿瘤的表达。方法收集五例患者的神经鞘瘤组织,采用免疫组化方法检测AQP1、AQP3的表达。结果 AQP1、AQP3在神经鞘瘤组织中都有表达,AQP1主要表达在微血管中,AQP3在整个组织中广泛表达。结论首次发现AQP1在神经鞘瘤微血管中表达,可能参与肿瘤血管新生;AQP3在神经鞘瘤细胞广泛表达,可能通过增加肿瘤细胞膜的水通透性而促进肿瘤的生长及浸润。两种水通道蛋白表达量与肿瘤发生发展的关系尚待扩大标本例数结合临床资料进一步分析。 |
| 关 键 词： | 人神经鞘瘤 AQP1 AQP3 表达 |
Expression of Water Channel Aquaporin-1 and Aquaporin-3 in Neurinoma |
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| QIAO Ying,LIU Jin,SU Wei-heng,et al.. Expression of Water Channel Aquaporin-1 and Aquaporin-3 in Neurinoma[J]. Chinese Journal of Laboratory Diagnosis, 2011, 15(4): 607-608 | |
| Authors: | QIAO Ying LIU Jin SU Wei-heng et al. |
| Affiliation: | QIAO Ying,LIU Jin,SU Wei-heng,et al.(Membrane Channel Research Lab,Northeast Normal University,Changchun 130024,China) |
| Abstract: | Objective To analyze the expression of aquaporin 1(AQP1) and aquaporin 3(AQP3) in peripheral neuroma.Methods Paraffin sections from five cases of Schwannoma tissues were gathered.The expression of AQP1 and AQP3 in the tumor tissues was analyzed by immunohistochemisty.Results Both AQP1 and AQP3 were detected to express in the Schwannoma tissues.AQP1 was selectively expressed in microvessels in the tumor.AQP3 was expressed extensively in Schwannoma cells.Conclusion We found for the first time that AQP1 and AQ... |
| Keywords: | AQP1 AQP3 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |