P-选择素与糖尿病肾病的相关性

目的观察不同阶段糖尿病肾病患者血清中P-选择素的水平变化，探讨其与糖尿病肾病的相关性。方法健康对照组为50名健康体检者，2型糖尿病患者150例分为正常蛋白尿组、微量白蛋白尿组及临床蛋白尿组，每组各50例。用酶联免疫吸附法检测血清P-选择素。结果所有糖尿病患者血清中P-选择素含量（17．36±6．19）ng／ml，均明显高于正常对照组（7．25±1．69）ng／ml]（P〈0．01）；微量白蛋白尿组（16．59±3．36）ng／ml]及临床白蛋白尿组（23．84±5．96）ng／ml]P-选择素又高于正常白蛋白尿组（12．34±2．31）ng／ml]（P〈0．01）；临床白蛋白尿组又高于微量白蛋白尿组（P〈0．01）；P选择素水平与空腹血糖、糖化血红蛋白、高敏C反应蛋白、尿白蛋白均呈正相关（r=0．54，0．68，0．97，0．71，P均〈0．01）。结论糖尿病肾病患者血清P-选择素的水平升高，可作为糖尿病肾病的检测指标之一。

The relationship between serum P-selectin and type 2 diabetic nephropathy

Objective To investigate the relationship between serum P-selectin and diabetic nephropathy of type 2 diabetes mellitus. Methods One hundred and fifty patients with diabetes mellitus and fifty healthy controls were enrolled. Subgroups of normal albuminuria （n=50）, microalbuminuria （n = 50） and clinical albuminuria （n= 50） were included. The serum levels of P-selectin were determined by particle-enhanced immunoturbidimetry. Results P-selectin showed higher level in diabetic patients than in healthy volunteers （17.4 vs 7.3 ng/ml, P〈0.01）. P selectin in T2DM was increased in the one-by one groups from NUAlb to MUAlb to CUAlb （12. 3 vs 16. 6 vs 23. 8 ng/ml）（all P〈0. 05： intergroup comparison）. FBG, HbAlc, hs-CRP and UAER were independently and significantly correlated with P- selectin. Conclusion P-selectin can be a reliable indicator for early impairment of renal function, and will be helpful for diagnosis of type 2 diabetic nephropathy.