| 白细胞介素-6基因启动子-572C/G、-634C/G的多态性与脑梗死的研究 |
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| 引用本文： | 潘云,韦叶生,黄建敏,覃羽华,潘国刚.白细胞介素-6基因启动子-572C/G、-634C/G的多态性与脑梗死的研究[J].中国实验诊断学,2011,15(4):627-630. |
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| 作者姓名： | 潘云 韦叶生 黄建敏 覃羽华 潘国刚 |
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| 作者单位： | 1. 右江民族医学院附属医院,检验科,广西,百色533000
2. 右江民族医学院附属医院,神经内科,广西,百色533000 |
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| 摘 要： | 目的探讨脑梗死患者白细胞介素-6（IL-6）基因启动子-572C/G-、634C/G的多态性及其血清水平与脑梗死的关系。方法采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）的分析方法,检测了106例脑梗死患者和92例健康对照者IL-6基因多态性,同时采用酶联免疫吸附试验检测IL-6的血清水平。结果脑梗死组IL-6水平显著高于对照组（P〈0.05）,IL-6-572C/G基因型和等位基因频率在脑梗死组和对照组比较,差异有显著性（P〈0.05）,与健康对照组相比,发现G等位基因携带者患脑梗死的相对风险度增加1.634倍（OR=1.634,95%CI=1.135~2.468）。携带G等位基因的脑梗死患者血清IL-6水平显著高于不携带者（P〈0.05）。IL-6基因-634C/G多态性在脑梗死组和对照组之间比较差异无显著性（P〉0.05）。结论 IL-6基因-572C/G多态性与脑梗死之间存在相关关系,其中G等位基因可能是脑梗死发病的遗传易感基因;携带G等位基因的个体可能通过促进IL-6的高度表达进而增加了脑梗死的发病风险。
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| 关 键 词： | 脑梗死 白细胞介素-6 基因多态性 |
Association of interleukin-6 gene promoter-572C/G and-634C/G polymorphisms in patients with cerebral infarction |
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| PAN Yun,WEI Ye-sheng,HUANG Jian-min,et al..Association of interleukin-6 gene promoter-572C/G and-634C/G polymorphisms in patients with cerebral infarction[J].Chinese Journal of Laboratory Diagnosis,2011,15(4):627-630. |
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| Authors: | PAN Yun WEI Ye-sheng HUANG Jian-min |
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| Institution: | PAN Yun1,WEI Ye-sheng1,HUANG Jian-min2,et al.(1.Department of Clinical Laboratory.2.department of internal neurology Affiliated Hospital of Youjiang Medical College For Nationalities,Guangxi Baise 533000,China) |
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| Abstract: | Objective To study polymorphism of the interleukin-6(IL-6) gene promoter-572C/G and-634C/G in patients with cerebral infarction,and to study the relation between serum levels and genotype of interleukin-6.Methods The polymorphism of IL-6 was detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method in 106 case cerebral infarction patients and 92 healthy persons,The serum level of IL-6 was determined by enzyme-linked immunosorbent assay(ELISA).Results cerebral infarction... |
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| Keywords: | Cerebral infarction Interleukin-6 Gene polymorphism |
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