慢性肝病和肝癌中丙型肝炎病毒感染的病理学研究

目的 研究广西肝细胞癌（ＨＣＣ）及慢性肝病病变组织中丙型肝炎病毒（ＨＣＶ）感染状况。探讨ＨＣＶ感染在肝癌发病中的应用。方法 用免疫组化ＳＰ法，检查２０１例病变肝组织中丙肝病毒核心区抗原（Ｈｅｐａｔｉｔｉｓ Ｃ Ｃｏｒｅ Ａｎｔｉｇｅｎ，ＨＣＡｇ）和乙肝病毒表面抗原（ＨＢｓＡｇ），分析各种肝脏病变中ＨＣＶ的感染状况及其与病变程度的关系。结果：１１６例ＨＣＣ和８５例慢性现中的ＨＣＶ感染率分别是４４．８

HISTOPATHOLOGY OF HEPATITIS C VIRUS INFECTION IN HEPATOCELLULAR CARCINOMA AND CHRONIC HEPATOPATHY

Objective:To investigate the frequency of Hepatitis C virus (HCV) infection in hepatocellular carcinoma(HCC) and chronic hepatopathy in Guangxi Method:116 cases of HCC and 85 cases of chronic hepatitis and cirrhosis were studied The HCV core antigen and HBsAg were detected in formalin fixed and paraffin embedded tissues by streptavidin peroxdase conjugated method Results:The positive rates of HCV in HCC and chronic hepatopathy were 44 8% and 28 2%,respectively,meanwhile HBsAg positive rates in those same cases were 80 2% and 83 5% Most of HCV positive cases (80 8%) showed co infection with HBV,only 8 4% of HCC cases were sololy associated with HCV infection The inflammation activity was more severe in liver tissues when both HBV and HCV were present in hepatocytes Conclusion:In these prevalent areas of HBV infection and risky regions of HCC,HCV has not become the main and sole etiogenic,neither is it a rare phenomenon HCV damages hepatocytes,and may enhance the carcinogenesis of HBV and/or aflatoxin B 1