Antithrombogenic effect of urokinase bound to collagen substrate with bifunctional antibodies |
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Authors: | I. P. Stepanova M. V. Tsybul'skaya S. P. Domogatskii |
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Affiliation: | (1) Group of Engineering Immunology, Cardiological Research Center, Russian Academy of Medical Sciences, Moscow |
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Abstract: | In vitro experiments simulating collagen-induced thrombogenesis in arteries damaged during angioplasty demonstrate a marked inhibitory effect of surface-bound urokinase. In contrast to free urokinase, bound enzyme is more effective in preventing platelet aggregation on the collagen surface. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N o 5, pp. 504–507, May, 1994 Presented by V. N. Smirnov, Member of the Russian Academy of Medical Sciences |
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Keywords: | transcutaneous transluminal coronary angioplasty collagen urokinase platelet aggregation |
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