Antithrombogenic effect of urokinase bound to collagen substrate with bifunctional antibodies

In vitro experiments simulating collagen-induced thrombogenesis in arteries damaged during angioplasty demonstrate a marked inhibitory effect of surface-bound urokinase. In contrast to free urokinase, bound enzyme is more effective in preventing platelet aggregation on the collagen surface. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 5, pp. 504–507, May, 1994 Presented by V. N. Smirnov, Member of the Russian Academy of Medical Sciences